Duphaston Tablet

1:18 AM
Duphaston
dydrogesterone
20 tablets

Solvay
Pharmaceuticals


COMPOSITION
Each tablet contains; dydrogesterone 10 mg

MODE OF ACTION
Dydrogesterone is an orally-active pcogestogen which produces a complete secretory endometrium in an oestrogen-primed uterus thereby providing protection for estrogen induced increased risk for endometrium hyperplasia and / or carcinogenesis. It is indicated of endogenous progesterone deficiency.
Dydrogesterone has no estrogenic, no androgenic, no thermogenic, no anabolic, and no corticoid activity.

INDICATIONS
  • Infertility due to luteal insufficiency.
  • Threatened abortion which is related to luteal deficiency.
  • Habitual abortion associated with proven progesterone deficiency.
  • Amenorrhoea (secondary)
  • Function uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.
  • Endometriosis
  • Dysmenorrnoea (primary) unrelated to an obvious physical cause such as uterine polyps, pelvic inflammatory disease or uterine leiomyomata. Adjunct to oestrogen replacement therapy.

POSOLOGY
Dosage in infertility due to tuteal insufficiency
10 mg dydrogesterone twice daily from the 11th to the 25th day of the cycle. The treatment is to be continued for at least 6 successive cycles, it is advised to continue this treatment during the first few months of a possible pregnancy, at dosages as are recommended for habitual abortion.

Dosage in threatened abortion which is related to luteal deficiency
Intial dose: 40 mg Duphaston at once, followed by 10 mg every 8 hours until symptom cease. Increase the dose by 10 mg every 8 hours when the symptoms recur or do not disappear during treatment. After the symptoms have disappeared, the effective dose should be maintained for 1 week and reduced gradually if the symptom is not recur.

Dosage in habitual abortion associated with proven progesterone deficiency
Treatment should be started as soon as possible, preferably, before conception. 10 mg dydrogesterone twice daily is to be given from the 11th to the 25th day of the cycle with continuous administration after conception. The treatment must be continued at any rate until the 20th week of pregnancy, then the dose can be reduced gradually.

Dosage in amenorrhoea (secondary)
  • An oestrogen once daily from day 1 to 25 of the cycle, and Duphaston 10 mg twice daily from day 11 to 25.
  • In oligomenorrhoea (functional amenorrhoea): 10 mg daily for five days will induce withdrawal bleeding in most patients.
Dosage in abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology [functional bleeding), such as submucous fibroids or uterine cancer
  • To arrest functional bleeding: 10 to 20 mg (1 to 2 tablets) one or two times a day for five to ten days.
  • To prevent further heavy bleeding: 10 to 20 mg (1 to 2 tablets) one or two times a day from the 11th to 25th day of the menstrual cycle and repeated cyclically as needed.
Dosage in endometriosis
10 mg twice daily starting with the 5" day of the menstrual cycle and ending on the 25th day. An alternative regimen is continuous administration.

Dosage In dysmenormoea (primary)
Unrelated to an obvious physical cause such as uterine polyps, pelvic inflammatory disease or uterine leiomyomi.
10 mg twice daily starting with the 5th day of the menstrual cycle and ending on the 25th day.

Adjunct to oestrogen replacement therapy
10 mg daily for 10 to 12 days per month is adequate for most patients.
20 mg daily for 10 to 12 days per month should be used only in the event unacceptable withdrawal bleeding.

OVERDOSAGE
Overdosage may cause nausea and withdrawal bleeding may occur in females. In case of overdoses or accidental ingestion, children should be observed closely although no medication is required. Gastric lavage or syrup of ipecacuanha may be given if deemed necessary. Therapy with Duphaston tablets must be adapted to the specific indications and therapeutic response of the individual patient, all dosage schedules assume the interval between menses to be 28 days.

PRECAUTIONS AND WARNING
Breakthrough bleeding may occur in a few patients. This can, however, be prevented by increasing the dosage. As a general rule, HRT should not be prescribed without a yearly generally physical examination, including a gynaecology examination. A mammogram on regular intervals Is generally advised. Breakthrough bleedings or abnormal findings at the gynaecological examination may be an indication for endometrial assessment.

Although not reported with the use of dydrogesterone, progestogens have been associated with the occurrence of several serious conditions including thromboembolism, stroke, myocardial infarction, hepatic adenoma, gall bladder disease, and hypertension, which have occurred in patients using oral contraceptives containing oestrogens and progestogens. The doctor should therefore be aware of these disorders and the drug should be discontinued immediately they occur or are suspected.

It is known that progestogens may cause some degree of fluid retention. Though this has never been reported for dydrogesterone, patients with epilepsy, migraine, asthma and cardiac or renal dysfunctions should be carefully observed while on therapy as fluid retention may be a factor.
Patients with history of psychic depression should be carefully observed and the drug discontinued if the depression recurs to a serious degree.
Any possible influence of prolonged dydrogesterone therapy on pituitary, ovarian, adrenal, hepatic or uterine function awaits further study.
Masculinisation has been observed In patients receiving certain progestogens.
Dydrogesterone is a progestogen, but to date female masculinisation has not been observed with this agent.
The use of progestational agents during the first four months of pregnancy is not recommended.
Detectable amounts of progestogens have been identified in the milk of mothers receiving them. The effect of this on the breastfed infant has not been determined.
Therefore Duphaston are not recommended for women who are breast feeding.

SIDE EFFECTS
  • Breakthrough bleeding may occur. This can, however, be prevented by increasing the dosage.
  • Nausea, breast tenderness, headache, bloated feeling, transient dizziness and skin reaction have occasionally been reported.
  • Menstrual changes, oedema, weight change are common.
  • Other adverse reactions that have been occasionally reported include hair abnormalities, vision changes, depression, confusion, abdominal pain, hepatitis, shortness of breath and slurred speech.
  • Although not reported with the use of dydrogesterone, an increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives containing oestrogens and progestogens: thrombophlebitis, pulmonary embolism, coronary thrombosis, cerebral thrombosis, cerebral haemorrhage, hypertension, gall bladder disease, liver tumors, congenital anomalies.
  • There is evidence of and association between the following conditions and the use of oral contraceptives, although additional confirmatory studies are needed: mesenteric thrombosis, neuro-ocular lesions e.g. retinal thrombosis and optic neuritis.

CONTRAINDICATIONS
Undiagnosed abnormal vaginal bleeding.
Thrombophlebitis or thromboembolic disorders. Cerebrovascular or coronary artery disease, or a past history of these conditions. Missed abortion. Known or suspected carcinoma of the breast. Known or suspected carcinoma of genital organs. Hepatic disease or dysfunction, a history of cholestatic jaundice or pruritus of pregnancy and in Dubin - Johnson syndrome and Rotor syndrome. History of herpes of pregnancy.
Sicklecell anaemia. Benign or malignant liver tumours which developed during the use of oral contraceptives.

STORAGE
Store below 30°C.

PACKING
Boxes of 20 tablets (1 blister of 20 tablets) Reg. No. DKI0681600617A1

ON MEDICAL PRESCRIPTION ONLY
HARUS DENGAN RESEP DOKTER


Manufactured by:
Solvay Pharmaceuticals B.V., Weesp, The Netherlands

Imported by:
PT. Solvay Pharma Indonesia, Jakarta, Indonesia

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13 Komentar
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I have had four Miscarriages over the years, and I have not been happy, I search for solution every where all to no avail, My condition became very complex to an extent of me having Miscarriage every five month. Until I got the contact of a doctor from the testimony of Others on the internet. I contacted him made him understand all I have passed through over the years, and he gave me his medication which I too for two month, and now am a mother of three month old Baby name John. If you have such problem, contact the doctor through his email at drsteve833@gmail.com
Am happy now.

Balas
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Dr.William product is a real cure to Tinnitus, I am 38 years old, I suffered from permanent tinnitus for about 4 years, mostly in my right ear... which means I've got this constant ringing in my ears, which has also made me somewhat deaf. It's like this Whee! noise in my head all the time. My T was more steady, this is due to prolonged exposure to the loud volume of concerts. Looking after your ears is unfortunately something you don't think about until there's a problem. I wish I'd thought about it earlier. There were days when I didn't know whether I would survive, I was so tormented by this symptoms. When I lay down to sleep it bothers me the most, As I lay my head on the pillow, it cancels out all the other ear. The GoodNews is that after using William Herbal medicine, Tinnitus is gone, try it also it going to work for you. There are real cure and do not be discouraged. Hang in there... Better days will come (email him on: drwilliams098765@gmail.com)

Balas
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I have beeen following this blog for a while now and today i decided to share my tinnitus story to encourage someone out there. I suffered from terrible tinnitus for 8 years after a constant exposure to loud noise. These noise sounded like a car horn in my right ear and grew worse at night when everywhere was calm and quiet, i lacked sleep and this ruined my psychological life. I had no idea the sound was damaging my hearing until it was too late and i had partial deafness, i had a constant ringing in my ear which always makes me feel like taking my own life. I tried so many drugs even B-vitamin supplements, especially B-5, visited so many audiologist, neuromonics and all was to no avail. I have not seen my ex for a long while and when we bumped into each other she knew i was not okay and i had to tell her all i was facing. She felt so sad but told me there is a cure which let me in amazement. That was when she told me about Dr. Joseph herbal medicine which gives a permanent relief to tinnitus symptoms and cures it. Lord know i needed help so i got the medicine and used it, that was when i met a breakthrough, i am perfectly okay now and i sleep calm without any stress and i hear clearly now. You too can get cured just contact him on (josephalberteo @ gmail. com) for advise and how to get the medicine. Thanks

Balas
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ALL THANKS TO DR WILLIAMS FOR GETTING MY WIFE OUT OF FIBROID WITH HIS HERB One of the greatest moments in this world is when you see your own wife put to bed, this awesome moments makes you a man and not just a man a real man. My wife suffered from Fibroid which made her unable to get pregnant and give us a child for almost 18 years with multiple surgeries done and none seemed to help the situation. I almost gave up but due to the love i had for her because i married her a virgin i had to find a way to help her. I told a member of my church who recommended Dr. williams to me, i contacted him and he sent me a medicine and this medicine shrinked it naturally in a weeks it was like magic but it's science. I am happy writing this because he delivered a baby girl. Do not loose hope too soon contact him on drwilliams098765@gmail.com and i am confident she will help you too.

Balas
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I GIVE THANKS TO DR WILLIAMS FOR GIVING ME LIFE.
He helped me with a fast cure to fibroid,and the size of it was .7cm, Then I started taking the medication for only one month, and now am completely cured from it. I was able to make it without any surgery, now I can live like every normal human and I can eat any food of my choice If you need such help, contact him via mail on drwilliams098765@gmail.com for advice,i hope this also help some one out there.

Balas
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ALL THANKS TO DR WILLIAMS WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM A TERRIBLE TINNITUS.
How can I ever stop thanking Dr William for the great deed he have done for me, i got an accident when I was 27 years old, from that day on i started experience ringing ear (tinnitus) i have taken all the western drugs prescribe by various doctor but to no avail . my tinnitus was very loud in the afternoon and I sleep less at night because of this problem i stop my work, few days later i was going through the Internet and I saw a post of so many people testifying about Dr William herbal remedies on how they was being cure for over many years suffering from tinnitus the story Really motivated me that I have to speak with my husband about it, and he said i should give him a try, i contacted Dr William and explain all i have be facing in my life. He assured me that everything is going to be fine if only I can get his herbal portion, i said yes and I requested for it, few days later the herb was sent to me in Kuwait,i started using it as instructed by Dr William for me to take it for 21 Days which I did, can you imagine after talking Dr William herbal medicine for just two weeks i started experience results, it was like a miracle,and now i am permanently cure from this terrible tinnitus, i promise that am going to publish his herb on thing my last breath for the great deed he have done for me. For those with similar ear problem should please contact him on his email address drwilliams098765@gmail his a good man and am proud of him.

Balas
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ALL THANKS TO DR WILLIAMS WITH HIS HERB I WAS CURED FROM A TERRIBLE TINNITUS.
. Is my pleasure to comment on this site and i thank the admin of this site for his/her great work so far. I really don’t know how to thank DR WILLIAMS for helping me get cured for over 20 year of suffering from a terrible tinnitus, my tinnitus started when i was 28 year i thought is going to end one day but even get worse as days went by,i have tried all western drugs prescribed by doctors but to no avail i lost total concentration, even at night i screams even more because the sounds become louder because everywhere is quiet. i came across DR WILLIAMS contact through a headline news on internet about how DR WILLIAMS have help so many people to get cured of tinnitus and so many other with similar body problem ,i contacted him and he told me how to get his herb,few day later he sent me the herbal portion which i take every morning for 21 days, and his medicine was able to restore me back to normal and now am very okay without any side effects whatsoever If you have Tinnitus, you can contact him on his email address drwilliams098765@gmail.com for help

Balas
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ALL THANKS TO DR WILLIAMS FOR THE GREAT DEED HE HAVE DON FOR MY DAUGHTER
My daughter suffered from a terrible tinnitus for more than 23 years which started after she turned 5 we all thought it will end but got even worse as days went by. We tried all several treatments and therapy prescribed by various doctors we met but to no avail, she lost total concentration and screamed most times. She usually tells me she hears hissing and ringing noises. This were steady noise that disrupted her entire life, even at night she screams even more because the sounds become louder because everywhere is quiet and she slept less because of this.It was during a casual conversation with a friend that i learned about dr Williams herbal medicine I was able to contact him on his email address. and give him all the necessary information that he needed,few day later he sent me the herbal portion and his medicine was able to restore her back to normal and she is very okay now without any side effects whatsoever. If you have Tinnitus, do not hesitate to contact him on drwilliams098765@gmail.com for advice and for his product. I hope this also helps someone out there

Balas
This comment has been removed by the author. - Hapus
This comment has been removed by the author. - Hapus
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I am Shelley from Los Angeles,California, I want to testify on how i got cured from tinnitus, I have suffered from ringing ears since the year 2011 with so mush pain,that i have to spend so mush money getting pain relief in the hospital, and I have visited several doctor ,but all to no avail, my world was gradually coming to an end because of the buzzing sound in my right ears, until i saw a post in a health forum about a herbal Dr Williams who use herbal portion in curing people from different kind of diseases including tinnitus, at first i doubted if it we be able to cure me, but i decided to give it a try, when i contacted this herbal doctor via his email, he prepared a herbal portion and sent it to me via courier service, when i received this herbal medicine, he gave me step by step instructions on how to apply it, when i applied it as instructed, i was completely free from tinnitus just for 1 months of usage,i we recommend this to all my friend family in the world today who still suffering from tinnitus you can contact him through his email on drwilliams098675@gmail.com for help.

Balas
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my wife have had two myomectomy, abdominal in 05/2012 and laparoscopy in 02/2014. she have never been pregnant; not to my knowing. I’m feeling hopeless and the fibroids are growing again. Doctor said that it look like she may need another myomectomy. I know that I have a fibroid the size of a goose egg(6cm).so i was online looking for help when i saw a post about this dr buba who has helped many with root ans herbs so i wrote to him he gave me some advice and told me what to do which i did then he sent a bottle of a herbal drug to me through DHL which she used for seven days and today she is fine with our second child already all thanks to him if you
are in my shoes or have any related sickness like cancer herpes hiv and aids Etc
CONTACT DR.BUBASPELLHOME@GMAIL.COM OR CALL and whatsapp +2348087937686 FOR URGENT HELP

Balas
avatar

my wife have had two myomectomy, abdominal in 05/2012 and laparoscopy in 02/2014. she have never been pregnant; not to my knowing. I’m feeling hopeless and the fibroids are growing again. Doctor said that it look like she may need another myomectomy. I know that I have a fibroid the size of a goose egg(6cm).so i was online looking for help when i saw a post about this dr buba who has helped many with root ans herbs so i wrote to him he gave me some advice and told me what to do which i did then he sent a bottle of a herbal drug to me through DHL which she used for seven days and today she is fine with our second child already all thanks to him if you
are in my shoes or have any related sickness like cancer herpes hiv and aids Etc
CONTACT DR.BUBASPELLHOME@GMAIL.COM OR CALL and whatsapp +2348087937686 FOR URGENT HELP

Balas

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