Reg. No. DKL8325200136A1
COMPOSITION AND DESCRIPTION
| Generic name | : | Trimetoquinol hydrochloride |
| Chemical name | : | (-)-1,2,3,4-Tetrahydro 1 (3,4,5-trimethoxybenzyl) isoquinoline-6, 7-diol hydrochloride monohydrate. |
- Trimetoquinol hydrochloride is odourless and consists of white crystalline powder having a bitter taste.
- It is slightly soluble in water, very slightly soluble in absolute alcohol and practically insoluble in acetone, absolute ether chloroform and benzene.
- Melting point : about 151°C (with decomposition).
| Product's names | Each mL contains | Description of the product |
|---|---|---|
| INOLIN® Pediatric drops | Trimeloquinol HCl 1,0 mg Alcohol 1,25% | Colourless to light yellowish brown clear solution with an aromatic odour pH:3,0-5,0 |
ACTION
Trimetoquinol hydrochloride dilates bronchial muscle selectively by stimulating Beta 2-receptors.
The bronchodilating action of Trimetoquinol hydrochloride (Beta 2-stimulating actions) was stronger than increasing action of heart rate (Beta 1-stimulating action), hypotensive action of diastolic blood pressure (Beta 2-stimulating action), and action to soleus muscle tension (Beta 2-stimulating action in experimental model tremor). Its blood concentration reached the maximum within 30 minutes after administration and then promptly decreased.
INDICATIONS
For the relief of bronchoconstriction associated with bronchitis, asthmatic bronchitis and bronchial asthma.
CONTRAINDICATIONS
INOLIN® is contraindicated in the patients who are hypersensitive to this product.
DOSAGE AND ADMINISTRATION
The following daily dosage is administered orally by dividing in 3 to 4.
- Under 1 year old : 1 - 2 mL
- 1 to 2 years old : 2 - 4 mL
- 3 to 4 years old : 4 - 6 mL
PRECAUTION
- In the even that the appropriate use of INOLIN® does not bring about good results, discontinue the administration of the drug as it is probable that the drug does not suit for such a patient. When the drug is given to infants or children, the correct use should be instructed and patients should be also carefully observed in the course of treatment.
- Great care should be exercised with respect to the successive and less excessive administration of INOLIN® because it is possible that the cardiac arrhythmia and in certain circumstances cardiac arrest will happen on the repeated excessive administration of INOLIN®, as with other sympathomimetic agents.
- Use with caution in case of :
- Hyperthyroidism
- Hypertension
- Heart diseases
- Diabetes mellitus
- The safety of the products in pregnant women has not been established.
- Use in the elderly should be under careful supervision.
Adverse reactions :
| 1. Cardiovascular system | : | Palpitation may occur occasionally, and alteration of blood pressure and precordial pain may appear rarely. |
| 2. Psychoneurotic system | : | Headache may occur occasionally. Tremor, dizziness, feverish sensation may also be encountered in a rare incidence. |
| 3. Digestive system | : | Occasionally, nausea and anorexia may appear. |
| 4. Hypersensitiveness | : | Discontinue the administration of the drug when hypersensitive symptoms such as eruption appear. |
| 5. Miscellaneous | : | Dry mouth may occur infrequently. |
Interactions :
Since the concurrent use of the drug with catecholamines such as Epinephrine and Isoproterenol may induce arrythmia or cardiac arrest in some cases, concurrent use is not recommended.
CAUTION IN HANDLING
This product is to be kept in 8° - 15°C.
To avoid possible contamination, handle this product cleanly after opening
PRESENTATION
Bottle of 30 mL net (supplied with measuring pipette).
ON DOCTOR'S PRESCRIPTION ONLY
HARUS DENGAN RESEP DOKTER
Under license from
TANABE SEIYAKU CO., LTD.
Osaka,Japan
Manufactured by
PT. TANABE INDONESIA
Bandung, Indonesia
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